Needing to avoid defeat to keep their hopes of a top-two finish alive, the Black Stars could revert to a four-man backline after lining up with five in front of Lawrence Ati-Zigi in their 3-2 loss to Portugal.
Mohammed Salisu - who conceded the penalty for Cristiano Ronaldo to open the scoring on that day - may be the one sacrificed, as Alexander Djiku and Daniel Amartey hold their spots.
Alidu Seidu will expect to fend off competition from Tariq Lamptey to hold his spot on the right, and Baba Rahman should bring up his 50th appearance for Ghana on the opposite side.
Thomas Partey and Salis Abdul Samed's spots in the middle are not up for debate, while Mohammed Kudus will continue to provide a spark from the number 10 role.
Osman Bukari should be the beneficiary of any possible formation change for Ghana, having come off the bench to reduce the deficit against Portugal before mimicking the iconic Ronaldo celebration.
Andre Ayew made history with an eighth World Cup appearance on Thursday - the most out of any current African player - and should keep his place over brother Jordan Ayew after marking the occasion with a goal.
A lurking Inaki Williams slipped at the vital moment as he attempted to steal the ball from the feet of Diogo Costa - who was not aware of the striker's presence behind him in the final few seconds - and the Athletic Bilbao man should get a second bite at the cherry here.
Ghana possible starting lineup: Ati Zigi; Seidu, Amartey, Djiku, Baba; Partey, Abdul Samed; Bukari, Kudus, A. Ayew; Williams