All of Manuel Neuer, Antonio Rudiger, Niklas Sule, Thomas Muller, Marco Reus, Leroy Sane and Ilkay Gundogan are absent for one reason or another, while Jamal Musiala and Armel Bella-Kotchap have both withdrawn injured.
With Neuer still recuperating from a broken leg, Barcelona's Marc-Andre ter Stegen can stake his claim for more regular appearances in between the sticks, as Kevin Trapp and the returning Bernd Leno provide backup.
One of six uncapped players in the ranks, Borussia Dortmund's Marius Wolf should make his Mannschaft debut at right-back, while RB Leipzig's David Raum sprints down the left.
AC Milan's Malick Thiaw is also among the players aiming to earn their first Germany caps, but Nico Schlotterbeck and Matthias Ginter could form an experienced centre-back pairing for the time being.
Familiar partners Joshua Kimmich and Leon Goretzka are set to form the base of the midfield, while Kai Havertz may fend off Florian Wirtz to occupy the number 10 role from the first whistle.
With no Sane at Flick's disposal, Timo Werner ought to strut his stuff on the left as Serge Gnabry holds the fort on the opposite flank, allowing Niclas Fullkrug to spearhead the attack.
Germany possible starting lineup: Ter Stegen; Wolf, Ginter, Schlotterbeck, Raum; Kimmich, Goretzka; Gnabry, Havertz, Werner; Fullkrug