In his absence, Michael Estrada could come back into the side to partner Leonardo Campana, although Fidel Martinez may be a better fit having hit eight goals in 35 international appearances.
Gonzalo Plata is expected to return to the starting XI on the left-hand side, after he came off the bench to find the net against Venezuela last time out, before their opponents scored a 91st-minute equaliser to see the game finish as a 2-2 draw.
Ayrton Preciado netted Ecuador's first goal in that game, and he should line upon the opposite flank, creating plenty of worries for Peru.
In the middle, 19-year-old Brighton & Hove Albion prospect Moises Caicedo has shown promise with some dynamic midfield performances alongside Jhegson Mendez, and they will partner up again on Wednesday.
Gustavo Alfaro is expected to stick with the familiar centre-back pairing of Robert Arboleda and Piero Hincapie, with full-backs Angelo Preciado and Pervis Estupinan completing the back four.
Goalkeeper Pedro Ortiz has begun to take over from captain Alexander Dominguez between the sticks at this tournament, and Alfaro should stick with his new man over the 34-year-old.
Ecuador possible starting lineup: Ortiz; Angelo Preciado, Arboleda, Hincapie, Estupinan; Plata, Caicedo, Mendez, Ayrton Preciado; Campana, Martinez