Messi scored the fastest goal of his career in the opening 80 seconds of Thursday's 2-0 win over Australia, but he has been given permission to miss the trip to Indonesia.
Lionel Scaloni has given his most valuable player the chance to begin his holiday before he links up with his new club Inter Miami in July.
The Argentina boss has also allowed Nicolas Otamendi and Angel Di Maria to leave the squad, and Scaloni could use Monday's contest to give some of his fringe players crucial game time.
Geronimo Rulli could replace Emiliano Martinez in between the posts, which would present the Ajax goalkeeper with the chance to make a rare international appearance.
German Pezzella is set to start in central defence alongside Leonardo Balerdi, with Nahuel Molina and Marcos Acuna set to operate as the two full-backs.
Scaloni may award Exequiel Palacios his first start for Argentina since June 2021, and he is likely to be joined in a midfield three by Leandro Paredes and Giovani Lo Celso.
After making his Argentina debut against Australia, Alejandro Garnacho is in contention to start for the first time in an Argentina shirt.
Garnacho is poised to feature in the forward line alongside Lucas Ocampos and Manchester City's Julian Alvarez, who is fresh from winning the treble with Pep Guardiola's side.
Argentina possible starting lineup:
Rulli; Molina, Balerdi, Pezzella, Acuna; Palacios, Paredes, Lo Celso; Ocampos, Alvarez, Garnacho