George Best, David Beckham, Eric Cantona and Cristiano Ronaldo all bore the shirt with pride, but the likes of Memphis Depay and Alexis Sanchez struggled to find form during their respective stints at Old Trafford.
Edinson Cavani was tasked with the job of dismissing the 'curse' that has been hanging over United since Ronaldo left.
And to his credit, the former Paris Saint-Germain frontman has done a pretty job of ending it once and for all so far.
While the 33-year-old is yet to get off the mark at Old Trafford, he has already made some telling contributions on the road this season.
His first Premier League goal came against Everton in a 3-1 success back in November, before coming off the bench to score a brilliant double in a dramatic 3-2 victory at Southampton later that month.
Cavani scored his second goal in as many outings against the Toffees in a 2-0 Carabao Cup quarter-final win before Christmas.
Most recently the Uruguay forward, who considered retirement after leaving the Parc des Princes at the end of last season, found the net as United maintained their impressive form by beating struggling Fulham on Wednesday night.
Cavani has a goal ratio of one strike every three games (four goals in 12 appearances), and looking at the below stats you can see how much of an improvement he has been on his predecessors who held the No.7 shirt - by some distance!
Has Edinson Cavani lifted the 'curse' of the No.7 since Cristiano Ronaldo's departure?
Michael Owen: 31 appearances, 5 goals
Antonio Valencia: 30 appearances, 1 goal
Angel Di Maria: 27 appearances, 3 goals
Memphis Depay: 33 appearances, 2 goals
Alexis Sanchez: 32 appearances, 3 goals
Edinson Cavani: 12 appearances, 4 goals
Ever since Cristiano Ronaldo left Manchester United to join Real Madrid in 2009, it's no secret that the club's iconic No. 7 shirt has proven too much for some to do justice.
Empoli 
Udinese 
CSKA Moscow 
Rubin 
Slovan Bratislava 
AC Milan 
Sparta Praha 
Atletico Madrid 
Valencia 
Barcelona 
Stade Brestois 29 
Bayer Leverkusen 
Red Bull Salzburg 
Bayern Munich 
Paris Saint Germain 
Inter 
RB Leipzig 
Manchester City 
Feyenoord 
Sporting CP 
Arsenal 
FC Rostov 
Spartak Moscow 
Aston Villa 
Juventus 
Celtic 
Club Brugge 
Dinamo Zagreb 
Borussia Dortmund 
Liverpool 
Real Madrid 
Monaco 
Benfica 
PSV 
Shakhtar Donetsk 
Lokomotiv Moscow 
Dinamo Moscow 
Anderlecht 
FC Porto 
AZ Alkmaar 
Galatasaray 
Dynamo Kyiv 
Viktoria Plzen 
Lazio 
Ludogorets 
Qarabag 
Lyon 
FC Heidenheim 
Chelsea 
FC Midtjylland 
Eintracht Frankfurt 
Manchester Utd 
Bodo/Glimt 
Nice 
Rangers 
Real Sociedad 
Ajax 
Tottenham 
Roma