The England captain travelled with the squad for the clash with Nuno Espirito Santo's former side and was given a mixed reception from Wolves fans after departing the team coach.
Kane was not deemed ready to face Manchester City or Pacos de Ferreira while he built up his fitness on the training pitches, but he is expected to earn his first minutes of the season in gameweek two of the Premier League season.
However, Santo has not selected Kane to start the encounter on Sunday afternoon, with the 28-year-old among the substitutes while Son Heung-min once again leads the line.
The visitors have named an unchanged lineup from their opening victory over Manchester City, as Lucas Moura and Steven Bergwijn provide support to Son while Oliver Skipp once again gets the nod in midfield.
Matt Doherty also starts on the bench against his former club, but Cristian Romero is not in the squad to face Wolves.
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