Fulham will play hosts at Craven Cottage as rivals Queens Park Rangers make the trip across town.
Marco Silva's side have enjoyed a largely encouraging start to the season but will be determined to bounce back following a 4-1 defeat against Coventry City before the international break.
As for Mark Warburton's side, it has been a campaign that has got off to an excellent start with QPR sitting in sixth position in the table.
However, a west London derby will surely be a big test for the Hoops as they target a potential play-off finish.
Here's everything you need to know ahead of the game.
Fulham v QPR: talkSPORT commentary
The Championship fixture is scheduled to take place on Saturday, October 16 with a kick-off time of 12.30pm.
talkSPORT 2 will have live coverage from Craven Cottage with Alex Crook and David Connolly which will get underway at 12pm.
Fulham v QPR: Team news
Marco Silva could make a number of changes to his side following defeat to the Sky Blues last time out.
Tosin Adarabioyo and Ivan Cavaleiro will be pushing for a recall while Joe Bryan could replace Antonee Robinson who is expected to be back late from international duty with the USA.
For Queens Park Rangers Mark Warburton could welcome Sam McCullum back into his starting XI.
The left-back has been out of action with a hamstring problem but could be fit to return.
Elsewhere Jordy de Wijs could be selected in defence while Charlie Austin and Andre Gray are likely to be completing to start the match alongside Lyndon Dykes in attack.
Fulham v QPR: What has been said?
Mark Warburton will miss the weekend's clash after testing positive for COVID-19.
He told the club website: "I tested positive after feeling unwell.
"Thankfully, I am double-jabbed and now appear to be over the worst of it.
"My time off last week coincided with the players having a pre-agreed few days off going into the international break.
"This week will see John Eustace prepare the squad for Saturday's game at Fulham. I have been in regular contact with John and will continue to be so until I resume my normal duties at the end of the week."