After ending a barren 22-year run without a win at Anfield in 2021, Everton have lost on both of their previous two trips across Stanley Park by two goals to nil.
The past two decades have produced some really dark Anfield evenings for Everton here though, and manager Sean Dyche will hope to avoid any repeats this weekend.
Ahead of Saturday's fixture, Sports Mole looks back at Everton's five worst results at Anfield.
5. Liverpool 3-1 Everton (2006)
The season after Everton beat Liverpool to fourth place in the Premier League, securing Champions League qualification for the first time, the Toffees never looked likely to replicate the feat.
Liverpool overshadowed Everton's accomplishment by winning the competition itself that season, and a 3-1 win over David Moyes's side the following campaign helped them to another season of UCL football.
What makes this result particularly embarrassing is that Liverpool were down to 10 men within 18 minutes after Steven Gerrard's dismissal, but Everton still found themselves 2-0 down shortly after half time.
Tim Cahill got Everton back into it on the hour mark but Andy van der Meyde's red card levelled up the playing field and Harry Kewell netted a late goal to clinch the win for the Reds.
4. Liverpool 4-0 Everton (2014)
The first of two 4-0 Anfield drubbings under Roberto Martinez came during a spell where Everton were playing some of the best football they had done for years.
Coming into the derby, Everton had lost just once in 14 games and were highly-fancied for a top-four finish, but after being simply destroyed in the first 50 minutes by a Luis Suarez and Daniel Sturridge-inspired Liverpool, the Toffees were left shellshocked.
Everton would go on to lose two of the next three games as well, and despite picking up form towards the end of the season, Martinez's side missed out on the top four with an incredible total of 72 points.
3. Liverpool 4-0 Everton (2016)
The second of those humbling defeats under Martinez all but sealed the Spaniard's fate, after Everton were truly humiliated in Jurgen Klopp's first derby as Liverpool boss.
In one of the most one-sided games in Premier League history, Everton were toothless even before Ramiro Funes Mori was sent off with the scoreline at 2-0, as Sturridge and Philippe Coutinho added two more goals to condemn Everton to a second 4-0 thrashing in as many years.
The stats made for incredibly grim reading on the blue half of Merseyside, as Liverpool racked up 37 shots to Everton's three, which unsurprisingly none were on target, and they then lost an FA Cup semi-final to Manchester United three days later, with Martinez getting the sack soon after.
2. Liverpool 1-0 Everton (2018)
While the result on paper does not look like a disaster, the manner of this defeat in 2018 was arguably the most sickening that any Everton fan has had to witness.
In a cagey and even encounter, Everton somehow did not find the net when Andre Gomes was culpable of one of the misses of the season with a close-range header, shortly after Yerry Mina had squandered a header of his own.
With the game ebbing out to a 0-0 draw, Virgil van Dijk's horribly sliced volley was seemingly sailing over in what would have been the final action, until Jordan Pickford bizarrely tried - and failed - to catch the ball from above his crossbar, making it bounce along the frame of the goal before landing right in front of Divock Origi on the goalline who scored one of the most freakish goals in Premier League history.
The Belgian's strike was clocked at 96 minutes and was ultimately the final action, as Everton threw away a point in one of the most farcical ways imaginable.
1. Liverpool 1-0 Everton (2020)
This 1-0 defeat at Anfield two years later certainly was catastrophic for the blue half of Merseyside, as they entered the fixture at Anfield as favourites for the first time in modern memory.
That was because Klopp heavily rotated his Liverpool side, bringing in many players for their full debuts as well as numerous fringe players, while Everton remained at full-strength.
In Carlo Ancelotti's first Merseyside derby, his side were guilty of missing golden opportunities but looked more and more toothless as the game went on despite Liverpool's backline consisting of the then-inexperienced trio of Neco Williams, Nat Phillips and Yasser Larouci.
Everton's humiliation was then compounded when an 18-year-old Curtis Jones scored his first Liverpool goal in spectacular fashion with 20 minutes to play and the youthful side held on as the Toffees suffered their most shameful ever Anfield defeat.