And Christian Eriksen is one man they will be keen to have back in action after picking up an injury that has ruled him out since January.
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Eriksen has been one of the key members of the Red Devils' squad this season and his presence has been missed.
The Dane suffered an ankle injury during an FA Cup tie with Reading three months ago and has not played a game since.
After the knock, Man United released a statement that confirmed that he would be out until 'late April or early May'.
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However, things are looking promising, with the midfielder nearing an early return to Erik ten Hag's side just when they need him most.
When will Eriksen return from injury?
Eriksen could be fit to return to action this weekend for Man United's game against Everton.
The midfielder has returned to full training with the Red Devils' team almost a month earlier than originally expected.
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Ten Hag provided a positive update on his injury this week saying: "He's returning into team training, so we have to see how quick he can now make the progress."
Then when asked if he is fit to play tonight, the Man United manager told reporters: "Not for [Wednesday] but he's returning on the pitch."
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Since signing on a free transfer after spending the second half of last season at Brentford, Eriksen has formed a brilliant partnership with Casemiro in United's midfield.
He has made 31 appearances across all competitions, scoring two goals and providing nine assists.
So having the Dane back in action could prove to be the difference in the race for a place in the Champions League.