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Borre spearheaded Frankfurt's attack in the first leg in Spain as Die Adler created chance after chance in an exciting first leg. The Colombian could've made the advantage even greater if not for a missed penalty in the second half, but goals before the break from Filip Kostic and Daichi Kamada ensured Eintracht returned home happy and in control. The latter was on target again on Sunday as Frankfurt came from behind to win 2-1 at home to Bochum. Goncalo Paciencia is available again after missing the first leg through suspension, while Danny da Costa could also return after pelvis issues as Eintracht look to join Bundesliga rivals and upcoming Matchday 27 opponents RB Leipzig in the quarter-finals.
Fekir briefly brought Betis level in Seville - the host city for this season's final - before Kamada restored Frankfurt's advantage. The France international was also sent off at the weekend - but is only suspended domestically - as Manuel Pellegrini's side edged Athletic Bilbao 1-0 in the league to end a five-game winless run across three competitions. Borja Iglesias got the goal and could be preferred over Willian Jose, who started the first leg, given the Spaniards must win to have a chance of progressing. Claudio Bravo saved the penalty in the reverse fixture, but was also far from convincing and therefore dropped at the weekend, with previous first-choice Rui Silva restored and unbeaten in his last six appearances.
Match stats
Borre has a goal and assist to show for his first seven Europa League outings with Frankfurt.
Kamada is Frankfurt's top scorer in Europe this season with four goals. He's also the highest scoring Japanese player in UEFA Cup/Europa League history with 10 in 17 games.
Frankfurt's win in the first leg extended their unbeaten run against Spanish opposition to six games.
The Eagles are unbeaten at home in their last three European home games.
Betis lost on their last visit to Germany, going down 4-0 to Bayer Leverkusen on Matchday 4 of this season's group stage.
Indeed, the Spanish side have only won one of their last five European away games, drawing two and drawing two.
Probable line-ups
Frankfurt: Trapp (c) - Tuta, Hinteregger, N'Dicka - Knauff, Sow, Jakic, Kostic - Lindstrom, Kamada - Borre
Out: Ache (hamstring), Durm (ineligible), Ilsanker (ineligible), Ramaj (knee)
Doubtful: da Costa (pelvis)
Coach: Oliver Glasner
Betis: Silva - Sabaly, Pezzella, Gonzalez, Miranda - Rodriguez, Carvalho - Canales (c), Fekir, Juanmi - Iglesias
Out: Akouokou (ineligible), Montoya (Achilles)
Doubtful:
Coach: Manuel Pellegrini