The sides will lock horns in a two-legged play-off for a place in Qatar this winter and the Liverpool duo will both be eager to make it.
Salah's Pharoahs will be desperate not only to make the World Cup, but also to earn revenge over the Lions of Teranga after they were beaten on penalties in the Africa Cup of Nations final.
Both sides breezed through the groups stages of the CAF World Cup qualification, remaining unbeaten throughout.
Egypt topped Group F, seven points clear of Pierre-Emerick Aubameyang's Gabon, while Senegal dominated Group H, dropping just two points.
Egypt vs Senegal: Date and kick-off time
The play-off first-leg tie will be held on Friday, March 25 and will kick off at 7.30pm UK time.
It is taking place at the Cairo International Stadium.
The return match will then be held on Tuesday, March 29 at 3pm at the Diamniadio Olympic Stadium in Dakar.
Egypt vs Senegal: TV channel and live stream
The game will not be shown live on UK television.
But fear not, you can watch all the action legally via free streaming service Mola TV.
Egypt vs Senegal: Team news
Salah is fit and raring to go for Egypt but Carlos Queiroz's men have a number of injuries.
Former West Brom star Ahmed Hegazy is out along with Akram Tawfik.
Ramadan Sobhi, formerly of Stoke and Huddersfield, is also absent, as is Mohamed Hany.
Senegal have no major injury worries and are expected to welcome back Ismaila Sarr, who had missed Watford's last three matches.
Egypt squad
Goalkeepers: Mohamed El-Shennawy (Al Ahly), Mohamed Abou-Gabal (Zamalek), Mohamed Sobhi (Pharco FC)
Defenders: Yasser Ibrahim, Mohamed Abdelmomen, Ayman Ashraf (Al Ahly), Omar Kamal (Future FC), Omar Gaber (Pyramids FC), Mahmoud Hamdy El-Wensh, Mahmoud Alaa, Ahmed Fatouh (Zamalek)
Midfielders: Hamdi Fathi, Amr El-Sulya, Mohamed Magdy Afsha (Al Ahly), Mohamed Elneny (Arsenal), Nabil Emad Dunga (Pyramids FC), Emam Ashour (Zamalek)
Forwards: Mohamed Salah (Liverpool), Omar Marmoush (VfB Stuttgart), Mahmoud Hassan Trezeguet (Istanbul Basaksehir), Mostafa Mohamed (Galatasaray), Marwan Hamdi (Smouha), Ahmed Sayed Zizo (Zamalek)
Senegal squad
Goalkeepers: Edouard Mendy (Chelsea, England), Alioune Badara Faty (Casa Sport), Bingourou Camara (Sporting Charleroi, Belgium)
Defenders: Bouna Sarr (Bayern Munich, Germany), Kalidou Koulibaly (Napoli, Italy) Abdou Diallo (PSG), Saliou Ciss (AS Nancy France), Pape Abou Cisse (Olympiakos, Greece), Fode-Ballo Toure (AC Milan, Italy), Youssouf Sabaly (Sevilla, Spain), Abdoulaye Seck (Antwerp, Belgium)
Midfielders: Idrissa Gana Gueye (PSG, France), Nampalys Mendy (Leicester City, England), Cheikhou Kouyate (Crystal Palace, England), Pape Matar Sarr (Metz, France), Moustapha Name (Paris FC, France), Loum Ndiaye (FC Porto, Portugal), Pape Gueye (Marseille, France)
Forwards: Sadio Mane (Liverpool, England), Ismaila Sarr (Watford, England), Famara Diedhiou (Alanyaspor, Turkey), Bamba Dieng (Marseille, France), Keita Balde Diao (Cagliari, Italy), Habib Diallo (Strasbourg, France), Mame Baba Thiam (Kayserispor, Turkey), Boulaye Dia (Villarreal, Spain)