The Dutchman has already become the first Reds head coach in history to oversee eight victories from his first nine matches thanks to Wednesday's 2-0 Champions League win over Bologna, where Alexis Mac Allister and Mohamed Salah were on target.
Liverpool also struck twice against Wolverhampton Wanderers in their most recent Premier League affair to leapfrog Manchester City at the top of the rankings, and they could open up a temporary four-point lead over the champions and Arsenal with victory in the 12.30pm kickoff.
Here, Sports Mole rounds up all of Liverpool's latest injury and suspension news ahead of their clash with Palace, who lie 18th in the table and are still searching for their maiden victory of the season.
Federico Chiesa
Status: Major doubt
Type of injury: Unspecified
Possible return date: October 5 (vs. Palace)
Federico Chiesa reported for training before the Bologna game with "some problems" and was not involved in the European success, making the Italian a huge doubt for the trip to Selhurst Park as well.
Harvey Elliott
Status: Out
Type of injury: Foot
Possible return date: October 27 (vs. Arsenal)
As all of Diogo Jota, Andy Robertson and Darwin Nunez were fit to take on Bologna, Chiesa's only other fellow injury victim is Harvey Elliott, who will not return from his foot fracture until after the international break.
LIVERPOOL'S SUSPENSION LIST
Liverpool have no players suspended for this match.