Emmanuel Dennis' goal against Manchester United ended the English impressive defensive record.
Dennis gave Club Brugge a 15th minute lead after connecting to Simon Mignolet's goal kick to beat a stranded Sergio Romero.
Nine minutes before the half-time break, Anthony Martial scored the equaliser as the Europa League encounter ended 1-1 at the Jan Breydel Stadium.
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The Nigerian's effort ended the Red Devils' run of 408 minutes without conceding across all competitions.
Ole Gunnar Solskjaer's side last conceded a goal in their 2-0 home defeat to Burnley on January 22.
With this result, United hold an important away goal heading into the competition's last-32 reverse fixture on February 27.
Before then, they welcome Watford to Old Trafford in a league game on Sunday, while Royal Charleroi visit Brugge in the Belgian topflight.