The West Londoners will be seeking revenge against the Red Devils after they lost 2-1 in the reverse fixture at Old Trafford in December.
Match preview
Chelsea were dealt a fresh blow in their quest to secure European football for next season after they were pegged back twice to draw 2-2 at home to the 10 men of relegation-threatened Burnley last weekend.
After Cole Palmer has his first-half opener - scored just moments after Lorenz Assignon was sent off for Burnley - cancelled out just two minutes after the interval by Josh Cullen, the Chelsea star netted a second to put the Blues back in front on the 78-minute mark. However, Dara O'Shea had the last laugh for the Clarets as he headed home Cullen's corner just three minutes later to rescue a valuable point for the visitors at Stamford Bridge.
Mauricio Pochettino admitted that his Chelsea side lacked 'heart and head' and were "missing something" in what he deemed a "must-win" match against Burnley. With just 11 victories on the board from 28 Premier League fixtures, the Blues are languishing in 11th place and sit four points behind the top seven, while they are eight points adrift of Thursday's opponents Man United in sixth.
Defensive frailties have been a key contributor to Chelsea's inconsistent campaign, with the Blues conceding exactly two goals across their last five games, while they have failed to keep a clean sheet in any of their last 11 matches across all competitions, shipping 22 goals in the process.
A run of five wins in seven Premier League home games bodes well for Chelsea heading into Thursday's contest, but their recent record against Man United leaves little to be desired, as they have failed to win any of their last 12 league meetings - not since November 2017 when Alvaro Morata secured a 1-0 home win have the Blues celebrated top-flight success over the Red Devils.
Man United were unable to follow up their euphoric seven-goal FA Cup quarter-final triumph over Liverpool before the international break with another victory, as they were forced to play out a 1-1 draw with Brentford in the Premier League last weekend.
The contest was goalless until substitute Mason Mount scored what seemed to be the winner for the Red Devils in the 96th minute. However, Brentford's persistence in the final third - registering a staggering 31 shots on Man United's goal - eventually told, as Kristoffer Ajer netted a dramatic 99th-minute equaliser.
Erik ten Hag was critical of his side's performance and admitted they "didn't deserve to win", with the Red Devils' latest setback leaving them eight points adrift of fifth-placed Tottenham Hotspur and in serious danger of missing out on a Champions League spot for next season.
Back-to-back league fixtures against Chelsea and leaders Liverpool are up next for Man United, who travel to the capital on Thursday having won only one of their last nine top-flight away games against London-based opposition, losing four of their last six during this run.
However, the Red Devils are unbeaten in their last five league visits to Stamford Bridge and are vying to win three consecutive matches against the Blues for the first time since September 1965. Victory on Thursday would also see Ten Hag's men complete their first league double over Chelsea since the 2019-20 campaign.
Chelsea Premier League form:
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W
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Chelsea form (all competitions):
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Manchester United Premier League form:
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Manchester United form (all competitions):
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Team News
Chelsea will be without Wesley Fofana (knee), Romeo Lavia (thigh), Christopher Nkunku, Reece James, Lesley Ugochukwu (all hamstring), Levi Colwill (toe), Carney Chukwuemeka (knock), Robert Sanchez and Trevoh Chalobah (both unspecified) due to injury.
Full-backs Malo Gusto and Ben Chilwell will both be assessed ahead of kickoff - the former picked up a hamstring injury in the closing stages of the draw with Burnley, while the latter missed out entirely due to a knee problem.
Axel Disasi could be tasked with filling in a right-back if Gusto is not deemed fit to start, and that would require Thiago Silva to return to the first XI to partner Benoit Badiashile at centre-back.
Palmer scored one of his 13 Premier League goals in the reverse fixture against Man United, and the former Manchester City youngster is expected to continue on the right flank, while Raheem Sterling and Noni Madueke will battle with Mykhaylo Mudryk for start in the final third.
As for Man United, Luke Shaw (muscle), Anthony Martial (groin), Tyrell Malacia (knee) all remain sidelined, while Raphael Varane, Victor Lindelof (both unspecified), Altay Bayindir and Jonny Evans (both muscle) are all doubtful.
The potential absence of both Varane and Lindelof could see Harry Maguire start in central defence alongside Lisandro Martinez, who made his long-awaited comeback from injury as a second-half substitute against Brentford.
Casemiro and ex-Chelsea man Mount are both in contention to start in midfield, although Ten Hag may be tempted to stick with Scott McTominay alongside Kobbie Mainoo - the Scotsman scored twice in the reverse fixture against Chelsea.
Amad Diallo is available to return from suspension, but neither he or Antony are expected to displace Alejandro Garnacho or Marcus Rashford on the flanks.
Chelsea possible starting lineup:
Petrovic; Disasi, Silva, Badiashile, Cucurella; Caicedo, Fernandez; Palmer, Gallagher, Sterling; Jackson
Manchester United possible starting lineup:
Onana; Dalot, Maguire, Martinez, Wan-Bissaka; Mainoo, McTominay; Garnacho, Fernandes, Rashford; Hojlund
We say: Chelsea 2-2 Manchester United
Although Man United may boast the psychological edge considering their recent record against Chelsea, there is little to separate these two under-performing and defensively vulnerable teams heading into Thursday's showdown.