An injury-hit Blaugrana could only take a point from a 1-1 draw with Granada on Monday night, as Domingos Duarte's second-minute opener was cancelled out by Ronald Araujo's equaliser right at the death.
The pressure is continuing to mount on the shoulders of Ronald Koeman, whose side now sit seventh in the table with eight points from their opening four matches.
Here, Sports Mole rounds up all of Barcelona's latest injury and suspension news ahead of the contest.
Sergio Aguero
Status: Out
Type of injury: Calf
Possible return date: Unknown
New arrival Sergio Aguero continues to recuperate following a serious calf injury, and the Argentine is unlikely to return before the end of October.
Ousmane Dembele
Status: Out
Type of injury: Knee
Possible return date: Unknown
Ousmane Dembele is recovering from knee surgery following the injury he suffered while representing France at Euro 2020, and the attacker will not be available for several weeks.
Ansu Fati
Status: Out
Type of injury: Knee
Possible return date: September 26 (vs. Levante)
Ansu Fati is closing in on a return to action following a serious knee injury, and reports have claimed that he may be ready for his comeback this weekend against Levante.
Martin Braithwaite
Status: Out
Type of injury: Knee
Possible return date: Unknown
Barcelona confirmed last week that Martin Braithwaite had undergone successful knee surgery, and the attacker will be sidelined for the foreseeable future.
Jordi Alba
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Jordi Alba picked up a hamstring injury in the Champions League against Bayern Munich and is reportedly facing at least another three weeks out of action.
Pedri
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Teenage starlet Pedri sustained a thigh issue during the defeat to Bayern and is not expected to be out for as long as Alba, but he will not be ready for Thursday.
Alejandro Balde
Status: Out
Type of injury: Back
Possible return date: Unknown
Deputising for the injured Alba against Granada, 17-year-old Alejandro Balde had to be forced off in the opening 45 minutes due to a back injury, and the full extent of the problem should be revealed later this week.
BARCELONA'S SUSPENSION LIST
Barcelona have no players suspended for this match.
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