The Catalan giants suffered a 4-2 loss to Osasuna in the league last weekend, but they remain top of the table, three points ahead of second-placed Real Madrid on the same number of matches (eight).
Hansi Flick's side will enter this match off the back of a positive result, meanwhile, beating Young Boys 5-0 in their second match of the 2024-25 Champions League on Tuesday night.
Here, Sports Mole rounds up Barcelona's injury and suspension news ahead of the clash with Alaves, who occupy 11th position in Spain's top flight, picking up 10 points from their first eight matches.
Dani Olmo
Status: Out
Type of injury: Hamstring
Possible return date: October 20 (vs. Sevilla)
Barcelona will again be without the services of Olmo due to the hamstring problem that he suffered during the team's 4-1 success over Girona, but he could return for the clash with Sevilla.
Ronald Araujo
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Araujo will be on the sidelines until the latter stages of this year due to the hamstring operation that he underwent in the middle of July, with a return date unclear at this stage of proceedings.
Gavi
Status: Out
Type of injury: Knee
Possible return date: Unknown
Gavi continues to recover from the serious knee injury that he suffered while representing Spain towards the end of last year, but he is expected to be available before the end of 2024.
Andreas Christensen
Status: Out
Type of injury: Achilles
Possible return date: November 6 (vs. Red Star Belgrade)
Christensen remains on the treatment table with an Achilles problem, and it is understood that the Denmark international will not be available until the start of November.
Marc Bernal
Status: Out
Type of injury: Knee
Possible return date: Unknown
Bernal suffered an ACL injury against Rayo Vallecano in the league earlier this season, and he is now expected to miss the remainder of the campaign.
Fermin Lopez
Status: Out
Type of injury: Thigh
Possible return date: October 20 (vs. Sevilla)
Fermin suffered a fresh thigh problem during a recent training session, and the Spain international will be on the sidelines until at least the clash with Sevilla after the international break.
Marc-Andre ter Stegen
Status: Out
Type of injury: Knee
Possible return date: Unknown
Barcelona will be missing their number one goalkeeper Ter Stegen for the remainder of the season due to the serious knee injury that he suffered in the 5-1 win over Villarreal.
Inigo Martinez
Status: Minor doubt
Type of injury: Muscle
Possible return date: October 6 (vs. Alaves)
Barcelona will need to assess Martinez after he was forced off against Young Boys with a muscular issue, but the centre-back did insist after the match that he would be available for the trip to Alaves.
BARCELONA'S SUSPENSION LIST
Barcelona have no players suspended for the La Liga clash.
Sparta Rotterdam 
AZ Alkmaar 
Southampton 
Liverpool 
Como 
Fiorentina 
Sevilla 
Rayo Vallecano 
Ajax 
Pec Zwolle 
Palermo 
Sampdoria 
Ipswich 
Manchester Utd 
Napoli 
Roma 
Moreirense 
FC Porto 
Leganes 
Real Madrid 
Lazio 
Bologna 
Empoli 
Udinese 
CSKA Moscow 
Rubin 
Slovan Bratislava 
AC Milan 
Sparta Praha 
Atletico Madrid 
Valencia 
Barcelona 
Stade Brestois 29 
Bayer Leverkusen 
Red Bull Salzburg 
Bayern Munich 
Paris Saint Germain 
Inter 
RB Leipzig 
Manchester City 
Feyenoord 
Sporting CP 
Arsenal 
FC Rostov 
Spartak Moscow 
Aston Villa 
Juventus 
Celtic 
Club Brugge 
Dinamo Zagreb 
Borussia Dortmund 
Monaco 
Benfica 
PSV 
Shakhtar Donetsk 
Lokomotiv Moscow 
Dinamo Moscow