The Gunners were thought to be keen to bring a new forward to the club over the summer but were unable to boost their options in that area of the field.
According to La Colina de Nervion, Mikel Arteta's side are keen on signing En-Nesyri, who has started the new season in impressive fashion, scoring twice and providing one assist in three La Liga appearances.
The report claims that Arsenal are keen on signing the forward in January but might have to wait until the end of the season to agree a deal with Sevilla.
En-Nesyri, who has four years left to run on his contract at Estadio Ramon, has scored 32 times in 81 appearances for Julen Lopetegui's side in all competitions.
Aubameyang, meanwhile, is seemingly approaching the latter stages of his time at the Emirates Stadium, with the 32-year-old thought to be looking for a route out of the club.