Brentford vs Manchester United will be rescheduled due to a COVID-19 outbreak at the Red Devils, leaving us with nine fixtures instead of ten.
At the top of the table, Manchester City, Liverpool and Chelsea are battling it out in the title race.
Then, fourth to eleventh are separated by just eight points as clubs look to make it into the European places.
At the other end, Norwich and Newcastle are in desperate need of points while Watford are only just ahead of Burnley in the relegation zone.
The action will now ramp up a notch with the Christmas schedule in full swing.
Club across the country will play a host of Premier League games in quick succession from now until the start of January.
And we've got a bumper week of action with nine midweek fixtures coming up.
talkSPORT will be your one-stop destination for all things football this week as we bring you all the matches exclusively live.
We'll have action on talkSPORT, talkSPORT 2 and the talkSPORT App on Tuesday, Wednesday and Thursday and here's what's in store…
On Tuesday, Manchester City host Leeds and Norwich boss Dean Smith welcomes his old club Aston Villa to Carrow Road.
The headline game on Wednesday sees a London derby clash between Arsenal and West Ham.
Elsewhere, Brighton take on Wolves, Burnley host Watford and Southampton are at Crystal Palace.
And Thursday sees three big ties including Liverpool v Newcastle.
Then, Leicester take on Tottenham and Chelsea entertain Everton.
To tune in to talkSPORT or talkSPORT 2, click HERE for the live stream.
App iPhone - Download from the Apple store
Android - Download from Google Play
Radio - talkSPORT is available across the United Kingdom via DAB digital radio and on 1089 or 1053 AM
TV - Listen to talkSPORT through your TV on the following channels: Sky: Channel 0108 Virgin Media: Channel 927 Freeview: Channel 723 Freesat: Channel 731