Jesse Marsch's men have won one of their last nine games in all competitions and that was against Cardiff in the FA Cup third-round replay.
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The Yorkshire side play with a lot of pace and energy but seem to make the wrong decisions in both boxes, and that is costing them.
Meanwhile, their opponents are currently 20th in League One and haven't won any of their last three FA Cup fourth-round ties.
The 'Owd Reds are embroiled in a relegation battle to stay out of League Two, but the chance to take a scalp in this competition is something that can't be passed up.
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Accrington v Leeds: talkSPORT coverage
This FA Cup fourth round tie is set to take place on Saturday, January 28.
Kick-off at the Wham Stadium is scheduled for 12:30pm.
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To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
Accrington v Leeds: Team news
For the hosts, fans' favourite Michael Nottingham returned from a long-term injury in the 1-0 win over Boreham Wood in the FA Cup third-round replay.
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But Jon Pritchard is out with an Achilles tendon rupture.
Meanwhile, the Whites will be without Stuart Dallas as he continues his recovery from a broken leg, while Adam Forshaw has missed the last five games.
But Luis Sinisterra and Crysencio Summerville are fully fit and ready to contribute after overcoming their injury problems.
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Accrington v Leeds: What has been said?
Accrington boss John Coleman after his side scraped past National League Boreham Wood: "We have got to improve, we have to find a way at home to try and emphasise and impress our style on the game, although that will be tough against Leeds.
"It is a massive boost to be in the fourth round and financially it might allow us to get one or two other reinforcements to the squad.
"Saturday is all about a day out for the fans, that will take care of itself."
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Accrington v Leeds: Match facts
This will be the first competitive meeting between Accrington Stanley and Leeds United since August 2014 when the sides met in a first round League Cup clash at Elland Road, with the Whites winning 2-1.
Leeds United eliminated Championship side Cardiff in the FA Cup third round after a replay, having lost their previous three ties against sides from a lower division. The Whites haven't knocked out two sides from a lower division in an FA Cup campaign since 2002-03 (three teams).
Accrington Stanley have lost each of their previous three ties in the FA Cup fourth round, with each defeat coming against sides from a higher division.
This is Leeds United's first FA Cup fourth round tie since 2016-17, when they lost 1-0 at non-league Sutton United. They haven't reached the FA Cup fifth round since 2015-16 under Steve Evans, eliminating Bolton in that season's fourth round.
Leeds have had three different players (Willy Gnonto, Patrick Bamford and Rodrigo) score twice in the FA Cup this season, the first time three players have scored 2+ goals for the Whites in an FA Cup campaign since 2009-10 (Jermaine Beckford, Luciano Becchio and Mike Grella) and first time as a top-flight side since 1978-79 (four players: Carl Harris, Frank Gray, Eddie Gray and Arthur Graham).