The defender picked up a thigh injury against Sparta Prague two Thursdays ago and has sat out the Reds' last two games, but he has been included in the France squad for the upcoming international window.
However, Klopp told reporters after last weekend's 1-1 draw with Manchester City that Konate had a "good chance" of featuring at Old Trafford, where Ryan Gravenberch - who has returned to training after an ankle issue - might be available too.
Fellow midfielder Bobby Clark is more of a doubt, though, having damaged his own ankle in Thursday's 6-1 Europa League success over Sparta, where he scored his first goal for the Reds en route to the quarter-finals.
Stefan Bajcetic (calf), Thiago Alcantara (muscle), Diogo Jota (knee), Ben Doak (knee), Joel Matip (knee), Alisson Becker (thigh), Curtis Jones (shin) and Trent Alexander-Arnold (knee) will not return this side of the international break either, but even an uninjured Clark would expect to cede his midfield spot to Alexis Mac Allister.
Alongside Wataru Endo and Dominik Szoboszlai, Mac Allister will form part of the three-pronged engine room behind the attacking trident, which should comprise Mohamed Salah on the back of a record-breaking goal on Thursday evening.
The Egyptian is now the first player to score 20 goals in seven straight seasons for Liverpool and came through the full 90 without any issues, so he should be given the nod alongside Darwin Nunez and Luis Diaz, the latter replacing Cody Gakpo despite the Dutchman's brace in midweek.
Further back, a fit-again Konate should demote Jarell Quansah to the bench, while Joe Gomez might be given the nod on the left-hand side over Andrew Robertson, having only completed the first half of Thursday's second leg with Sparta.
As a result, a slight defensive tweak would see Robertson demoted for Virgil van Dijk, as Conor Bradley and Caoimhin Kelleher complete the visitors' shield.
Liverpool possible starting lineup:
Kelleher; Bradley, Konate, Van Dijk, Gomez; Mac Allister, Endo, Szoboszlai; Salah, Nunez, Diaz