The Blues continue to be inconsistent under Mauricio Pochettino, following four-goal defeats against Liverpool and Wolverhampton Wanderers by scoring three goals in victories at Aston Villa and Crystal Palace.
Although the EFL Cup final is on the horizon, Chelsea head into this contest sitting in 10th position in the standings and eager to further close the gap on the top seven.
Here, Sports Mole rounds up Chelsea's latest injury and suspension news ahead of their trip to the North-West to face the defending champions.
Thiago Silva
Status: Major doubt
Type of injury: Groin
Possible return date: February 17 (vs. Man City)
Thiago Silva was forced off with a groin issue on the hour-mark against Palace on Monday. Although Chelsea are yet to provide an update, it is highly unlikely that the veteran Brazilian will be available on Saturday.
Wesley Fofana
Status: Out
Type of injury: Knee
Possible return date: Unknown
Wesley Fofana is yet to make an appearance for Chelsea this term due to a serious knee injury and the defender is unlikely to return before next season.
Lesley Ugochukwu
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Lesley Ugochukwu sustained a hamstring injury in the loss to Wolves on Christmas Eve and the midfielder has since been ruled out until at least the end of the month.
Robert Sanchez
Status: Minor doubt
Type of injury: Knee
Possible return date: February 17 (vs. Man City)
Robert Sanchez is making good progress in his recovery from a knee injury and is pushing towards returning to the substitutes' bench in due course.
Marc Cucurella
Status: Out
Type of injury: Ankle
Possible return date: Unknown
Marc Cucurella was another victim of that defeat to Everton, sustaining an ankle injury which required surgery, and the left-back is not expected to return until March at the earliest.
Reece James
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Reece James underwent hamstring surgery just before Christmas and the Chelsea captain is facing a race against time to be fit before the end of the season.
Romeo Lavia
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Romeo Lavia's long-awaited return to the Chelsea side following a lengthy spell out with an ankle injury was cut short by a thigh problem, and it remains to be seen when the midfielder will return to the first-team fold, Pochettino already acknowledging that it will not be during February.
Benoit Badiashile
Status: Out
Type of injury: Groin
Possible return date: Unknown
Benoit Badiashile was forced off during the closing stages against Aston Villa on February 7 with a groin injury. According to reports, the Frenchman will spend a month on the sidelines, potentially ruling him out until the middle of March.
CHELSEA'S SUSPENSION LIST
Chelsea have no suspended players for this match.