After suffering a heartbreaking extra-time defeat in the EFL Cup final to Liverpool, the Blues returned to winning ways when they beat a spirited Leeds United side 3-2 at Stamford Bridge to secure their place in the FA Cup quarter-finals.
Mauricio Pochettino's men now shift their focus back to the Premier League as they endeavour to move closer to the top seven and boost their European qualification hopes.
Here, Sports Mole rounds up Chelsea's latest injury and suspension news ahead of the contest with Thomas Frank's side.
Thiago Silva
Status: Major doubt
Type of injury: Groin
Possible return date: March 2 vs. Brentford
Thiago Silva has missed the last three games with a groin injury sustained against Crystal Palace on February 12. The Brazilian has returned to light training but it remains to be seen if he will be ready to return this weekend.
Christopher Nkunku
Status: Out
Type of injury: Unspecified
Possible return date: March 30 (vs. Burnley)
Christopher Nkunku, who has been troubled with injuries throughout his debut campaign at Chelsea, has been ruled out for up to four weeks with an unspecified issue.
Marc Cucurella
Status: Out
Type of injury: Ankle
Possible return date: March 11 (vs. Newcastle)
Marc Cucurella last played for Chelsea in an away victory over Everton in early December in which he sustained an ankle injury that required surgery. The left-back was recently pictured in light-training, but Saturday's will likley come too soon for the Spaniard.
Carney Chukwuemeka
Status: Out
Type of injury: Ankle
Possible return date: March 11 (vs. Newcastle)
Carney Chukwuemeka twisted his ankle during training earlier this month and has subsequently missed the last three games. As things stand, it appears unlikely that the midfielder will be ready to return for Saturday's contest.
Benoit Badiashile
Status: Out
Type of injury: Groin
Possible return date: March 11 (vs. Newcastle)
Benoit Badiashile is nursing a groin problem and has subsequently missed the last four matches, but the Frenchman could be in a position to return to action later this month.
Wesley Fofana
Status: Out
Type of injury: Knee
Possible return date: Unknown
Wesley Fofana is yet to make a single appearance for Chelsea this season due to a long-term knee injury and the defender is facing a race against time to return before the end of the campaign.
Reece James
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Reece James underwent hamstring surgery just before Christmas and it remains to be seen whether the Chelsea captain will recover before the end of the season.
Lesley Ugochukwu
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Lesley Ugochukwu sustained a hamstring injury in the loss to Wolverhampton Wanderers on Christmas Eve and there is currently no timescale on his potential return.
Romeo Lavia
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Romeo Lavia, who has made just one substitute appearance since joining Chelsea last summer, is still recovering from a thigh injury that has kept him in the treatment room since the end of last year, and there is currently no timescale on his potential return.
CHELSEA'S SUSPENSION LIST
Chelsea have no suspended players for this match.