The Citizens have never won UEFA's prize competition, but with the addition of Erling Haaland, they will feel this is their year.
City have dominated the Premier League since Pep Guardiola's arrival, but they have yet to translate that form to Europe.
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Meanwhile, Sevilla haven't beaten an English side in the Champions League group stages since 2007 and have only won one of their last eight in this competition.
City managed a 1-1 draw against Aston Villa on Saturday
Sevilla were comfortably beaten 3-0 by Barcelona
Sevilla: Bono, Navas, Gudelj, Nianzou, Telles, Rakitic, Delaney, Acuna, Gomez, Isco, Carmona
Manchester City: Ederson, Cancelo, Dias, Akanji, Gomez, Rodri, De Bruyne, Silva, Grealish, Foden, Haaland
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