The Red Devils are still pursuing four pieces of silverware this season and advanced to the Europa League quarter-finals in midweek courtesy of a 5-1 aggregate win over Real Betis.
Erik ten Hag's men have sent Everton, Reading and West Ham United packing to reach the final eight - winning 3-1 each time - as they seek a 13th FA Cup crown and first since the 2015-16 campaign.
Here, Sports Mole rounds up Man United's latest injury and suspension news ahead of the clash with the Cottagers, who defeated Leeds United in the fifth round.
Anthony Martial
Status: Minor doubt
Type of injury: Hip
Possible return date: March 19 (vs. Fulham)
Anthony Martial has now been building up his fitness in training for a couple of weeks since recovering from a hip issue, but having not been involved against Betis, a question mark is still hanging over his head for the FA Cup.
Christian Eriksen
Status: Out
Type of injury: Ankle
Possible return date: April 29 (vs. Aston Villa)
Christian Eriksen was a casualty of Man United's cup success over Reading at the end of January, and his ankle problem will keep him sidelined until the final few weeks of the season.
Donny van de Beek
Status: Out
Type of injury: Knee
Possible return date: Unknown
Donny van de Beek's season was ended by a serious knee injury at the start of January, cruelly denying him the chance to finally ignite his Old Trafford career under Ten Hag.
Alejandro Garnacho
Status: Out
Type of injury: Ankle
Possible return date: Unknown
Alejandro Garnacho left Old Trafford on crutches last weekend after sustaining an ankle injury in the draw with Southampton, and while no timeline has been placed on the 18-year-old's recovery, he is expected to spend at least a few weeks out.
Antony
Status: Minor doubt
Type of injury: Illness
Possible return date: March 19 (vs. Fulham)
Antony was unavailable for Thursday's second leg versus Betis due to illness, but the attacker should have a strong chance of recovering in time for Sunday.
MANCHESTER UNITED SUSPENSION LIST
Casemiro
Return date: April 15 (vs. Nottingham Forest)
Casemiro received his second red card of the season in last week's draw with Southampton, and he serves the first of a four-game domestic ban here.