The Gunners currently sit eight points clear of Man City who have a game in hand on the league leaders.
Advertisement
Mikel Arteta's side are closing in on their first title since 2004 but with 10 games left this season, there is plenty of work still to do.
And they are yet to face a trip to face the Citizens who are more than used to dealing with the pressures of a title fight.
In the previous meeting at the Emirates in February, it was Pep Guardiola's men who came out on top.
Advertisement
Jack Grealish and Erling Haaland sealed a 3-1 win late on and City will be hoping to repeat that result.
When is Man City vs Arsenal?
Man City host Arsenal at the Etihad Stadium on Wednesday, April 26.
The game is scheduled to kick off at 8pm.
Advertisement
Both teams will have six matches left of the season after they meet meaning the result in Manchester will likely set up a thrilling end to the Premier League campaign.
City have beaten Arsenal in each of their last seven clashes at the Etihad while the Gunners have only won there once since 2010.
Advertisement
Premier League title race run-in
Advertisement
Arsenal have the advantage in the title race but they have a difficult run-in as we head towards the end of the season.
Alongside the upcoming title clash at City, the Gunners also have to face Liverpool and Chelsea as well as Newcastle and Brighton in their final few games.
They end the campaign with two more straight-forward looking games against Nottingham Forest and Wolves.
Advertisement
City, of course, are hoping that Arteta's side slip up and hand them a shot at the title.
However, the Citizens also have to face the same standout opponents, taking on Liverpool and Chelsea as well.
They have six away games in their last ten fixtures while their final game is at Brentford.
Guardiola's men may also struggle with fatigue and focus as they remain in three competitions whereas the Gunners are only in one.
Advertisement
City face a two-legged tie against Bayern Munich in the Champions League quarter-finals while also meet Sheffield United in the FA Cup semi-finals.
Dnipro-1 
Dynamo Kyiv 
West Ham 
Liverpool 
Shakhtar Donetsk 
Bayern Munich 
Eintracht Frankfurt 
FC Augsburg 
Werder Bremen 
RB Leipzig 
Borussia Dortmund 
SC Freiburg 
VFL Wolfsburg 
Manchester Utd 
Burnley 
Sampdoria 
Como 
Juventus 
AC Milan 
Everton 
Brentford 
Bayer Leverkusen 
VFB Stuttgart 
Atletico Madrid 
Athletic Bilbao 
Elche 
Espanyol 
Stade Lavallois 
Bordeaux 
Benfica 
SC Braga 
Lazio 
Verona 
Aston Villa 
Chelsea 
Paris Saint Germain 
Le Havre 
NEC Nijmegen 
AZ Alkmaar 
Inter 
Torino 
ST Mirren 
Rangers 
Tottenham 
Arsenal 
Spartak Moscow 
Lokomotiv Moscow 
Dundee 
Celtic 
Nottingham Forest 
Manchester City 
Bologna 
Udinese 
Fiorentina 
Sassuolo 
Napoli 
Roma 
Lyon 
Monaco