Muller and Lewandowski are first and second respectively in goals for both Bayern Munich and the Bundesliga, with scoring figures that have etched their names into German football's folklore.
The pinnacle for each, outside of their combined 12 league titles trophies, was the single-season scoring record, one Muller set in 1972 with 40 in 34 games, and it looked like it would never be broken.
Lewandowski came close in 2019/20 with 34, but a year later was when he finally made history and the celebratory t-shirts came out following his 41st goal that took the 49-year record.
Leaving in the summer of 2022 to join Barcelona for £35million, Lewadowski's replacement, Sadio Mane, faltered, while he went and won LaLiga, seemingly cementing his legacy.
However, it's not often that Bayern miss, and with Kane, they certainly haven't.
Making up for their Mane mistake a summer later, the England captain took no time at all to get off the mark, and impressed so much that even Lewandowski had to comment.
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"When I think about my record and the 41 goals in just 29 games, I still find it incredible," he said.
"That was crazy. 'The Hurricane' is a great player, but the Bundesliga is not an easy league either. I think he needs a bit of time and you can't tell yet.
"I myself would never have thought that Gerd Muller's record could be broken after 40 years. I can't explain today how I did it either. Every piece of the puzzle has to be perfect."
It was back in September that Lewandowski made his judgement, and now it's looking very premature.
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With two goals in a 3-0 win over top four challengers Stuttgart, Kane made it 20 goals in just 14 games in the middle of December.
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That's more than last season's Golden Boot winners, Christopher Nkunku and Niclas Fullkrug, and the fastest anyone has ever reached the tally.
Should Kane continue scoring at this current rate, he'll reach 48 for the season, so inevitably the questions have already started.
"No, it's still a bit too far away to think about," he commented at the weekend.
"I'm sure you'll repeat that every time I score, but I just have to keep focusing on my game. I want to keep doing what I do: keep scoring goals.
"If I'm close in April, I'll of course try to achieve the record. It was Robert with 41 goals, as far as I know.
"There's still a long way to go. Robert has been fantastic for the club and is one of the best strikers in the world in recent times. We're still a long way from that, but I just have to keep doing what I'm doing."
If Kane does make it past the 41-goal mark, one of his teammates surprisingly thinks it's more about the no.9's selflessness than anything else.
"I knew he was good - but not that he was THAT good," Kingsley Coman said after the Stuttgart win.
"It's great to play with such a striker. I'm used to playing with great strikers, and it's really great when you have someone like that whose goals you can rely on.
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"But the difference is that he is not selfish. Usually most nines are selfish. They have to score a lot of goals, that's the only way they can do it.
"He's scoring so many goals at the moment, but he plays such crazy good passes to Leroy [Sane], to me, to Jamal [Musiala], to everyone. That's what makes the difference."