The Lilywhites have enjoyed a two-week break from competitive action after going down 2-1 to Wolverhampton Wanderers on February 17, a contest which Pedro Porro (strain) and Destiny Udogie (knee) both missed.
Postecoglou is hopeful that Udogie's problem will heal in time for the Italian to be involved on Saturday, but with Porro being ruled out for a couple of weeks, it is unclear whether he will be fit to take his place in the side.
Tottenham have also lost the unfortunate Ryan Sessegnon to a second serious hamstring injury in the last 12 months, while Manor Solomon (knee) and Fraser Forster (foot) are also out of contention.
With Udogie expected to return to the fold, Ben Davies is braced to drop back down to the bench, but uncertainty over Porro's fitness levels will benefit Emerson Royal's chances of earning an increasingly rare Premier League start.
Micky van de Ven and Cristian Romero will line up unchallenged in front of Guglielmo Vicario, though, and the same can be said for Yves Bissouma and Pape Sarr at the base of the midfield.
Dejan Kulusevski's place in attack is certainly safe after the Swede extended Spurs' scoring streak in the Premier League to 37 matches two weeks ago, and despite competition from Brennan Johnson and Timo Werner, the trio of James Maddison, Son Heung-min and Richarlison should be expected to hold their places too.
Tottenham Hotspur possible starting lineup:
Vicario; Royal, Romero, Van de Ven, Udogie; Bissouma, Sarr; Kulusevski, Maddison, Son; Richarlison