Knowing that victory in Copenhagen would see them avoid relegation to League B, an already-depleted France side witnessed Jules Kounde and Mike Maignan both come off in Thursday's win over Austria.
Kounde's thigh problem opens the door for Arsenal's William Saliba to start in the backline, and if Maignan's calf injury does not let up in time, Alphonse Areola should get the nod in goal.
Saliba ought to be joined by Raphael Varane and Benoit Badiashile in a three-man defence, with the latter earning high praise for his performance on his senior international debut in midweek.
Badiashile's Monaco teammate and fellow debutant Youssouf Fofana also put in a good shift and will expect to partner Real Madrid's Aurelien Tchouameni in the middle - a combination familiar to Monegasques fans.
Jonathan Clauss and Ferland Mendy both completed the full 90 minutes in midweek, but Deschamps is unlikely to ponder any unenforced alterations given what is at stake, as Benjamin Pavard and Adrien Truffert wait in the wings.
Antoine Griezmann's spot in the number 10 role is seemingly safe, while Olivier Giroud and Kylian Mbappe should continue their partnership in the final third after scoring the goals against Austria.
Giroud's header represented his 49th strike for his country, and the AC Milan striker needs just three more to surpass Thierry Henry's 51 and become the record goalscorer for the French men's team.
France possible starting lineup: Areola; Saliba, Varane, Badiashile; Clauss, Fofana, Tchouameni, Mendy; Griezmann; Mbappe, Giroud