The Blues produced arguably their best display of the season last week to beat Aston Villa 3-1 in the FA Cup to seal a place in the fifth round.
Mauricio Pochettino's men were 3-0 up early in the second half and looked fluid throughout.
They will now hope to take that form into the league as they look to bounce back from shocking defeats to Liverpool and Wolves.
Meanwhile, Palace are slipping into a relegation dogfight and are set to be without plenty of key players.
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Crystal Palace XI: Henderson, Munoz, Andersen, Richards, Mitchell, Lerma, Hughes, Wharton, Franca, Ayew, Mateta.
Subs: Johnstone, Ward, Tomkins, Clyne, Riedewald, Ozoh, Schlupp, Ahamada, Edouard.
Chelsea XI: Petrovic, Gusto, Disasi, Silva, Chilwell, Caicedo, Fernandez, Gallagher, Madueke, Palmer, Jackson.
Subs: Bergstrom, Chalobah, Colwill, Gilchrist, Casadei, Chukwuemeka, Mudryk, Sterling, Nkunku.
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