The 29-year-old made it to within one game of glory at the tournament's last edition in 2019 but the Teranga Lions fell to a 1-0 loss to Algeria.
Mane has been on a mission to help Senegal claim their first ever Nations Cup trophy this time around though.
Aliou Cisse's side beat Equatorial Guinea 3-1 on Sunday to set up a last four clash with 2013 runners-up Burkina Faso.
Burkina Faso vs Senegal: Date and time
This Africa Cup of Nations semi-final clash will take place on Wednesday, February 2.
The match is scheduled for a 7pm kick-off in the UK at the Stade Omnisport Ahmadou Ahidjo in Yaounde.
Burkina Faso have failed to defeat Senegal in each of the last four meetings between the sides since 2006.
Burkina Faso vs Senegal: TV Channel and Live stream
This match will be broadcast live on Sky Sports Premier League with live coverage starting from 6:55pm.
Sky Sports customers can live stream this via the app using their mobile, tablet or computer devices.
If not, you can purchase a Sky Sports Day Pass from NowTV for £9.99.
The game will also be screened for FREE on BBC Three from kick-off at 7pm.
Burkina Faso vs Senegal: Team news
The hosts will be without Lorient youngster Dango Ouattara, following the red card he received after he scored the winner against Tunisia last time out.
Djibril Ouattara is also a doubt after he picked up an injury in that quarter-final clash which was his first appearance of the tournament.
Senegal meanwhile have a clean bill of health to contend with as Mane is set to feature once again alongside Chelsea's Edouard Mendy.
Crystal Palace star Cheikou Kouyate could be among the Premier League continent to start the game after his impressive cameo against Equatorial Guinea.
Burkina Faso vs Senegal: What has been said?
Mane has insisted he is willing to make sacrifices to help Senegal at the AFCON.
"It's my job (to be ready to play everywhere). I have to do it because I think it's really important for me," said Mane.
"It's important for the boys to make sure we win the game, so to win you have to do everything and make all the sacrifices necessary.
"I think all the games, for me, are the best. Of course I know people always look for nice football, try to create chances and score and that's normal.
"But as a football player you can't expect this all the time. Doing this without winning makes no sense."