Erik ten Hag's side overcame Copenhagen 1-0 in their midweek Champions League battle, while the treble winners put BSC Young Boys to the sword 3-1, and here Sports Mole rounds up the team news for both clubs.
MANCHESTER UNITED vs. MANCHESTER CITY
MANCHESTER UNITED
Out: Jadon Sancho (disciplinary), Lisandro Martinez (foot), Luke Shaw (muscle), Amad Diallo (knee), Tyrell Malacia (knee)
Doubtful: Casemiro (ankle), Aaron Wan-Bissaka (thigh)
Sports Mole's predicted XI: Onana; Dalot, Varane, Maguire, Reguilon; Casemiro, Eriksen; Antony, Fernandes, Rashford; Hojlund
MANCHESTER CITY
Out: Manuel Akanji (suspended), Kevin De Bruyne (hamstring)
Doubtful: None
Sports Mole's predicted XI: Ederson; Walker, Stones, Dias, Gvardiol; Rodri, Silva; Doku, Alvarez, Foden; Haaland
For data analysis of the most likely results, scorelines and more for this match please click here.