Either Leeds United or Plymouth Argyle will make the journey to Premier League territory to face the winner, and here Sports Mole rounds up the team news for both clubs.
ASTON VILLA vs. CHELSEA
ASTON VILLA
Out: Morgan Rogers (cup-tied), Emi Buendia (knee), Tyrone Mings (knee), Jhon Duran (hamstring), Lucas Digne (thigh), Nicolo Zaniolo (unspecified), Ezri Konsa (knee)
Doubtful: None
Sports Mole's predicted XI: Martinez; Cash, Carlos, Lenglet, Moreno; McGinn, Kamara, Luiz, Bailey; Diaby, Watkins
CHELSEA
Out: Lesley Ugochukwu (hamstring), Wesley Fofana (knee), Robert Sanchez (knee), Reece James (thigh), Marc Cucurella (ankle), Romeo Lavia (quadriceps), Levi Colwill (tendon), Trevoh Chalobah (thigh)
Doubtful: None
Sports Mole's predicted XI: Petrovic; Gusto, Disasi, Badiashile, Chilwell; Chukwuemeka, Fernandez; Palmer, Nkunku, Mudryk; Jackson
For data analysis of the most likely results, scorelines and more for this match please click here.