The Citizens enter the contest in buoyant mood after securing a 3-1 away victory over Copenhagen in the first leg of their last-16 tie in the Champions League on Tuesday.
However, Pep Guardiola has confirmed that a few of his players are either sidelined or need assessing before this weekend's fixture with Chelsea, who are seeking to win their third away game in a row.
Here, Sports Mole rounds up Man City's latest injury and suspension news ahead of their encounter with Mauricio Pochettino's side.
Josko Gvardiol
Status: Out
Type of injury: Ankle
Possible return date: February 24 (vs. Bournemouth)
Guardiola confirmed after Tuesday's win at Copenhagen that Josko Gvardiol will be sidelined for "two weeks or three weeks" with an ankle ligament injury.
Jack Grealish
Status: Minor doubt
Type of injury: Muscle
Possible return date: February 17 (vs. Chelsea)
Jack Grealish was forced off midway through the first half against Copenhagen with a "muscular" injury according to Guardiola, and the attacker is set to be assessed in the next few days to determine whether he can feature this weekend.
Bernardo Silva
Status: Minor doubt
Type of injury: Ankle
Possible return date: February 17 (vs. Chelsea)
Bernardo Silva was taken off midway through the second half against Copenhagen after sustaining a "big knock" to his ankle according to Guardiola, and the playmaker has subsequently emerged as a doubt for Saturday's clash with Chelsea.
Mateo Kovacic
Status: Minor doubt
Type of injury: Knee
Possible return date: February 17 (vs. Chelsea)
Mateo Kovacic has missed City's last two games with a knee problem, but Guardiola has confirmed that the midfielder is set to return to training on Thursday or Friday and could therefore be in a position to return to the matchday squad for the clash against his former club Chelsea.
Sergio Gomez
Status: Minor doubt
Type of injury: Unspecified
Possible return date: February 17 (vs. Chelsea)
Sergio Gomez has missed each of City's last three games in all competitions with an unspecified issue. The left-back remains a doubt but is unlikely to feature in Guardiola's first-team plans for Saturday's fixture anyway.
MANCHESTER CITY'S SUSPENSION LIST
Manchester City have no suspended players for this match.