Last season's runners-up are currently second in Group A, one point behind leaders Paris Saint-Germain after three matches played.
City beat Bruges 5-1 last month away from home and victory again will seem them move five points clear of the Belgian side with two games remaining.
Man City v Club Bruges: Date and kick-off time
This Group A tie is due to take place on Wednesday, November 3.
It is taking place at the Etihad and kick-off is at 8pm.
City next face a crunch clash against PSG before finishing their group stage journey in Germany to take on RB Leipzig.
Man City v Club Bruges: TV channel and live stream
The Champions League clash will be live on BT Sport 3 with coverage starting at 7:15pm.
BT Sport subscribers can live stream this match via the app on their computer, mobile and tablet devices.
talkSPORT's Adrian Durham will bring you updates from this match on Kick-Off 'Around the Grounds'.
Man City v Club Bruges: Team news
Ferran Torres is the only major absentee for the home side as he continues to nurse a foot injury he suffered on international duty with Spain.
Aymeric Laporte is available however with the ban he picked up for his red card in the defeat to Crystal Palace only active for domestic fixtures.
City otherwise have a clean bill of health with Ilkay Gundogan rested on Saturday having only made his comeback against West Ham last week.
Bruges meanwhile will be without Eder Balanta through suspension after he picked up three Champions League bookings.
Man City v Club Bruges: What has been said?
"We have to take it seriously to make a good performance," said Guardiola.
"This game gives us an incredible step forward to qualify for the Champions League last 16."
"This is more important than United," he added.
"In the Premier League there are many games, here just six [in the group] and three left. They are decisive in the third and fourth - the most important games."