Nordi Mukiele has undergone surgery on a hamstring problem and will not play again this term, joining Neymar (ankle) and Presnel Kimpembe (Achilles) on the long-term list.
Christophe Galtier's predicament is not helped by another problem for Renato Sanches, who has been ruled out for up to four weeks with an adductor concern sustained in last weekend's win at Nice.
However, the PSG boss is hopeful of welcoming Marco Verratti back from a muscular issue - the Italian would be a straight swap for Sanches in an ideal world - but Fabian Ruiz and Warren Zaire-Emery are waiting in the wings if need be.
Carlos Soler and Vitinha should be in no danger of losing their spots in the midfield-heavy formation, as Achraf Hakimi and Nuno Mendes continue out wide - the latter would normally face competition from Juan Bernat, but his Spanish counterpart is currently dealing with an ankle problem.
Once again setting up in a 3-5-2 system, Galtier should go with the unaltered rearguard of Marquinhos, Sergio Ramos and Danilo Pereira in front of Gianluigi Donnarumma, while the two-man strikeforce, as ever, picks itself.
Kylian Mbappe needs just one more goal for a record-breaking 139th in Ligue 1 - taking him clear of Edinson Cavani and into first place in PSG's all-time charts - and the 24-year-old appears to have shaken off a hip niggle in time to link up with Lionel Messi.
Paris Saint-Germain possible starting lineup: Donnarumma; Pereira, Marquinhos, Ramos; Hakimi, Verratti, Soler, Vitinha, Mendes; Messi, Mbappe