All of Erling Haaland (foot), Jeremy Doku (muscle) or John Stones (ankle) were absent from the squad for last weekend's 2-0 Premier League win over Sheffield United, and it would be a shock to see Guardiola throw caution to the wind against the Terriers here.
Kevin De Bruyne was on the bench for the Premier League champions against the Blades last weekend, but having failed to earn any minutes as a substitute, he should also be kept waiting for his comeback start.
As ever, Guardiola ought to tinker with his starting lineup for the visit of the struggling Terriers - who are 21st in the Championship - starting with Stefan Ortega coming in for Ederson in between the sticks.
Rico Lewis and Sergio Gomez are vying for starts in the full-back areas too, but Ruben Dias and Manuel Akanji could still provide a touch of experience as Man City's central partnership.
Kalvin Phillips's unsuccessful Etihad stint should soon come to an end, but the Englishman is still in line for a rare start in the engine room, where another bit-part player in Matheus Nunes ought to join him.
Both Oscar Bobb and Micah Hamilton will be eyeing valuable minutes in the final third too, where Julian Alvarez and Phil Foden should also be strutting their stuff.
Manchester City possible starting lineup: Ortega; Lewis, Dias, Akanji, Gomez; Nunes, Phillips; Bobb, Foden, Hamilton; Alvarez