Pep Guardiola has confirmed that Josko Gvardiol is ruled out for between two and three weeks with an ankle ligament injury, while both Jack Grealish and Bernardo Silva have emerged as doubts after coming off with respective muscle and ankle problems in Tuesday's 3-1 win at Copenhagen in the Champions League.
Sergio Gomez is also doubtful having missed the last three games with an unspecified issue, but the Citizens could be boosted by the return of former Chelsea midfielder Mateo Kovacic, who is set to take part in training on Thursday or Friday after missing the last two matches with a knee problem.
The absence of Gvardiol is set to see Nathan Ake, another ex-Chelsea man, operate on the left side of a back four, as captain Kyle Walker most likley continues at right-back. Ruben Dias, meanwhile, could be joined in central defence by one of John Stones or Manuel Akanji, and either of the latter two may also be tasked to drift into midfield to partner Rodri.
Guardiola has a few attacking options who could replace Grealish on the left flank; Jeremy Doku started against Chelsea in a thrilling 4-4 draw at Stamford Bridge three months ago and could be recalled on Saturday, but the Belgian winger is set to be rivalled by Phil Foden for a starting berth.
Kevin De Bruyne, who scored in midweek along with Foden and Bernardo, is expected to retain his place in the final third, while Julian Alvarez was rested against Copenhagen and will be pushing to start in behind central striker Erling Haaland, who netted twice against Chelsea earlier this season.
Manchester City possible starting lineup: Ederson; Walker, Dias, Ake; Stones, Rodri; Bernardo, De Bruyne, Alvarez, Foden; Haaland