The Portugal international was pictured with a protective strap on his wrist on Friday, and Red Devils head coach Erik ten Hag said during his press conference that Fernandes was a doubt for Monday's match.
The attacker's incredible record when it comes to being fit and available is expected to continue, though, with the 29-year-old set to retain his spot in the side.
Scott McTominay suffered a knee injury in the latter stages of the clash with Burnley last weekend but is expected to be available, and he could come into the middle of midfield.
Ten Hag could make just the one change from the side that started the 1-1 draw with Burnley, with McTominay replacing Christian Eriksen.
Casemiro will again be required in the middle of the defence, but Jonny Evans could make the bench, having returned to training on Thursday following a spell out with a muscular issue.
Marcus Rashford has not yet recovered from the fitness problem that he picked up in the FA Cup semi-final against Coventry City, while Willy Kambwala, Raphael Varane, Anthony Martial, Lisandro Martinez, Victor Lindelof, Luke Shaw and Tyrell Malacia remain on the sidelines through injury.
Antony scored against Burnley last time out and is likely to retain his spot down the right, with Alejandro Garnacho and Rasmus Hojlund also featuring in the final third of the field.
Manchester United possible starting lineup: Onana; Wan-Bissaka, Casemiro, Maguire, Dalot; McTominay, Mainoo; Antony, Fernandes, Garnacho; Hojlund