The Gunners came from two goals behind to draw with Chelsea and preserve their unbeaten Premier League start but the tough games continue to come thick and fast.
The 2-2 draw meant Arsenal's only defeat this season came in Europe, with a surprising loss away to Lens.
Mikel Arteta's side now sit second in Group B and can ill-afford another slip-up, with only three points separating top and bottom.
Europa League holders Sevilla have endured a tough start to their season but managed a 1-1 draw with Real Madrid last time out.
Live commentary: talkSPORT website stream HERE, via the app HERE/ Live stream: TNT Sports 1
Arsenal XI: Raya; White, Saliba, Gabriel, Tomiyasu; Jorginho, Rice, Odegaard; Saka, Jesus, Martinelli.
Subs: Ramsdale, Hein, Smith Rowe, Nketiah, Kiwior, Cedric, Trossard, Vieira, Nelson, Elneny, Havertz, Zinchenko.
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