New arrival Inigo Martinez is yet to take to the field with his new teammates due to a foot problem, which has been plaguing the former Athletic Bilbao man since April.
Martinez is still on the road to recovery and was unable to take part in Wednesday's 5-3 loss to Arsenal, but Xavi's squad is otherwise in good shape after Alejandro Balde shook off an ankle problem.
The left-back should be one of several players considered for recalls to the starting lineup here, while Jules Kounde is also a contender to take the place of Sergino Dest in the right-back role.
Neither Ronald Araujo nor Andreas Christensen covered themselves in glory versus Arsenal, and the latter's spot could now come under threat from Eric Garcia, while Marc-Andre ter Stegen ought to captain the side in between the sticks.
The returning Oriol Romeu could continue at the base of the midfield, but Franck Kessie and Frenkie de Jong's fresh legs may be preferred over Pedri and Ilkay Gundogan respectively.
The same can be said for Ousmane Dembele and Ansu Fati in the final third, although Ferran Torres's strike off the bench against Arsenal should not be enough to earn him a start over Robert Lewandowski.
Barcelona possible starting lineup: Ter Stegen; Kounde, Araujo, Garcia, Balde; Kessie, Romeu, De Jong; Dembele, Lewandowski, Fati