The Citizens trail the reigning champions 3-2 after a spectacular late collapse at the Etihad in the first leg of their knockout play-off.
They led heading into the closing stages thanks to an Erling Haaland double, but a couple of poor defensive errors allowed the visitors to flip the match with Jude Bellingham scoring a last-gasp winner.
Since then, City have thrashed Newcastle, so their confidence should be high again, but it remains a monster task to turn the tie around.
talkSPORT commentary: Live stream HERE, app HERE.
Real Madrid XI: Courtois, Valverde, Rudiger, Asencio, Mendy, Tchouameni, Ceballos, Bellingham, Rodrygo, Vini Jr., Mbappe.
Subs: Lunin, Mestre, Alaba, Vallejo, Garcia, Vazquez, Guler, Endrick, Modric, Camavinga.
Man City XI: Ederson, Khusanov, Stones, Dias, Gvardiol, Gonzalez, Gundogan, Bernardo, Foden, Savinho, Marmoush.
Subs: Ortega Moreno, Carson, Ake, Kovacic, Haaland, Grealish, Doku, De Bruyne, Nunes, Lewis, McAtee.
You can follow all of the action in our live blog below...