The West Midlands outfit head into the contest with the top-flight leaders looking to kick-start their campaign having recently dropped down to ninth place in the table.
Unai Emery has reacted to the 1-1 draw with Ipswich Town on Saturday by naming an attack-minded XI, including handing a first Villa start to Manchester United loanee Marcus Rashford.
Marco Asensio also begins a game for Villa from the start for the first time with Emery making a total of three changes to his first XI.
Tyrone Mings is the other player to come into the team, the centre-back taking the spot of Boubacar Kamara who suffered a hamstring injury at the weekend.
Jacob Ramsey and Donyell Malen have also dropped out of the team, but injury doubt Matty Cash has been selected among the replacements.
Liverpool make one change
Despite suggestions of fatigue against Wolverhampton Wanderers on Sunday, Arne Slot has made just the one alteration to his Liverpool side.
Curtis Jones - who served a suspension for that game - has been recalled in place of Luis Diaz, either the England international or Dominik Szoboszlai in line to start on the left.
Ibrahima Konate retains his place at centre-back having been withdrawn at half time versus Wolves due to Slot being concerned that the defender may get sent off.
Aston Villa XI: Martinez; Garcia, Disasi, Mings, Digne; Asensio, Tielemans, McGinn, Rashford; Rogers; Watkins
Subs: Olsen, Zych, Cash, Bogarde, Maatsen, Malen, Ramsey, Jimoh-Aloba
Liverpool XI: Alisson; Alexander-Arnold, Konate, Van Dijk, Robertson; Jones, Gravenberch, Mac Allister; Salah, Jota, Szoboszlai
Subs: Kelleher, Endo, Diaz, Nunez, Chiesa, Elliott, Tsimikas, Quansah, Bradley
Written by
Darren Plant