The game is being played in Serbia due to the UEFA-imposed ban on Belarus from hosting continental and international matches.
Match preview
This will be Switzerland's first outing since being thrashed 6-1 by Portugal in the last 16 of the World Cup.
Despite that humiliation on the big stage, the Swiss have stuck with Murat Yakin as manager, evidently giving him credit for infamously edging out Italy in their qualifying section for the finals in Qatar.
However, since then, Switzerland have won only five of 13 matches, albeit, a lot of them coming at the World Cup and a tough UEFA Nations League group.
Their respectable Nations League campaign did see them beat all of the sides in a section containing Portugal, Spain and Czech Republic.
They are a very efficient side at navigating qualification sections, having missed only one of the last 10 major tournaments - Euro 2012.
The Swiss will fancy their chances again being the highest-ranked side in a relatively weak group this time around.
Romania, Kosovo and Israel are expected to be the only realistic challengers and it is likely they will all be targeting second spot behind Switzerland, as two of those sides have never reached a major tournament while competing in Europe.
Given Belarus' close ties with Russia, there is some controversy that they are still allowed to compete at all in UEFA competitions.
The European football governing body remain content at preventing matches from being hosted in the country as a sufficient sanction for now, but unlike Russia would have, Belarus have very slim hopes of causing many problems for nations in Group I.
All four of their friendly matches since the sanctioning being played away from home against sides from Asia shows the reluctance from European nations to associate with the country too, so they will get fewer opportunities to test themselves against high-level opponents.
No competitive wins in 13 matches including 10 defeats dating back two years shows why Belarus are such underdogs for this clash.
Having no home advantage will also be to the detriment of the team who were just two matches away from qualifying for Euro 2020 after winning their Nations League group in 2019.
That was only the second occasion where they have come close to reaching a major finals, after a defeat in Wales in their final qualifier for the 2002 World Cup saw them narrowly miss out on a playoff spot.
After being ranked as high as 36th in the world back in 2011, during the heydays of BATE Borisov performing stoutly in Europe, Belarus now find themselves barely inside the top 100.
Belarus form (all competitions):
D
L
L
D
W
L
Switzerland form (all competitions):
W
L
W
L
W
L
Team News
Plenty of talent at some of Europe's biggest clubs should feature for Switzerland here, including Granit Xhaka, Manuel Akanji, Yann Sommer and Denis Zakaria.
There are a number of injury concerns for Yakin to deal with though, as Xherdan Shaqiri, Gregor Kobel, Jordan Lotomba and Andi Zeqiri have all pulled out of the squad.
Fabian Schar and Haris Seferovic are among the biggest names left out from the side that went to Qatar at the end of 2022 for the World Cup.
Breel Embolo scored two goals in Qatar and comes into the international break in great form this season, having reached double figures for the first time in a top five European league at Monaco.
Only seven of Belarus' 23-man squad play their football outside Belarus or Russia, and of those seven, none play in any of Europe's top 20 leagues.
It is a relatively inexperienced squad too, with Denis Polyakov the only member with more than 30 caps for his country.
Striking options are limited to just Dinamo Minsk duo Uladzimir Khvashchynski, who has not scored an international goal since 2013, and the uncapped Vladislav Morozov.
Belarus possible starting lineup:
Plotnikov; Volkov, Polyakov, Yuzepchuk, Khadarkevich, Malkevich; Bocherov, Yablonsky, Ebong, Klimovich; Khvashchynski
Switzerland possible starting lineup:
Sommer; Widmer, Akanji, Elvedi, Rodriguez; Xhaka, Freuler, Zakaria, Sow; Okafor, Embolo
We say: Belarus 0-3 Switzerland
These two nations met in qualification for Euro 2000 and in a friendly in 2017 with Switzerland winning all three encounters to nil.