The Magpies will face Brighton & Hove Albion in their first away fixture of the new season on August 13, while a difficult end to the month will see them take on both Manchester City and Liverpool.
A busy October will see Eddie Howe's side play six league matches, as the campaign will be halted in November and December due to the 2022 World Cup.
Newcastle's final match of the 2022-23 season, meanwhile, will be against Chelsea on May 28.
Newcastle United's 2022-23 Premier League fixtures in full:
August
6 - Nottingham Forest (H)
13 - Brighton & Hove Albion (A)
20 - Manchester City (H)
27 - Wolverhampton Wanderers (A)
31 - Liverpool (A)
September
3 - Crystal Palace (H)
10 - West Ham United (A)
17 - Bournemouth (H)
October
1 - Fulham (A)
8 - Brentford (H)
15 - Manchester United (A)
19 - Everton (H)
22 - Tottenham Hotspur (A)
29 - Aston Villa (H)
November
5 - Southampton (A)
12 - Chelsea (H)
December
26 - Leicester City (A)
31 - Leeds United (H)
January
2 - Arsenal (A)
14 - Fulham (H)
21 - Crystal Palace (A)
February
4 - West Ham United (H)
11 - Bournemouth (A)
18 - Liverpool (H)
25 - Brighton & Hove Albion (H)
March
4 - Manchester City (A)
11 - Wolverhampton Wanderers (H)
18 - Nottingham Forest (A)
April
1 - Manchester United (H)
8 - Brentford (A)
15 - Aston Villa (A)
22 - Tottenham Hotspur (H)
25 - Everton (A)
29 - Southampton (H)
May
6 - Arsenal (H)
13 - Leeds United (A)
20 - Leicester City (H)
28 - Chelsea (A)