The Citizens were forced to settle for a 1-1 draw at Newcastle United last weekend and have since cruised to a 4-0 victory away against Slovan Bratislava in the Champions League on Tuesday night.
Fulham, meanwhile, secured a narrow 1-0 victory at Nottingham Forest in their most recent Premier League game last weekend and sit sixth in the table, just three points behind Man City in second.
Here, Sports Mole rounds up Man City's latest injury and suspension news ahead of the contest with Marco Silva's side.
Rodri
Status: Out
Type of injury: Knee
Possible return date: Unknown
Rodri is ruled out for the rest of the 2024-25 season after suffering knee ligament damage last month.
Kevin De Bruyne
Status: Out
Type of injury: Groin
Possible return date: October 20 vs. Wolves
Kevin De Bruyne has missed the last four matches with a groin injury and the playmaker is not expected to return until after the international break.
Nathan Ake
Status: Out
Type of injury: Muscle
Possible return date: October 20 vs. Wolves
Nathan Ake has missed Man City's last six matches with a muscle problem and, like De Bruyne, is not expected to return until after the international break.
Oscar Bobb
Status: Out
Type of injury: Leg fracture
Possible return date: Unknown
Oscar Bobb sustained a leg fracture in training in mid-August and he is not expected to return to first-team action until the end of the year at the earliest.
MANCHESTER CITY'S SUSPENSION LIST
Manchester City have no suspended players for this match.