Carlo Ancelotti's side beat Stuttgart 3-1 on matchday one, but were pegged back late on by rivals Atletico Madrid in the derby at the weekend.
LILLE vs. REAL MADRID
LILLE
Out: Angel Gomes (suspended), Hakon Arnar Haraldsson (leg), Ismaily (unknown), Samuel Umtiti (knee), Ethan Mbappe (muscle), Ngal'ayel Mukau (ankle)
Doubtful: Nabil Bentaleb (illness)
Sports Mole's predicted XI: Chevalier; Tiago Santos, Diakite, Alexsandro, Gudmundsson; Andre, Andre Gomes, Cabella; Zhegrova, David, Sahraoui
REAL MADRID
Out: Kylian Mbappe (thigh), David Alaba (knee), Dani Ceballos (ankle), Brahim Diaz (thigh)
Doubtful: Thibaut Courtois (muscle), Fran Garcia (Achilles tendon)
Sports Mole's predicted XI: Lunin; Carvajal, Eder Militao, Rudiger, Mendy; Valverde, Camavinga, Tchouameni; Bellingham; Rodrygo, Vinicius Junior
For data analysis of the most likely results, scorelines and more for this match please click here.