The Gunners top Group B after picking up six points from their opening three games.
Mikel Arteta's men are in a healthy position despite a shock defeat in France to Lens in early October.
They beat Sevilla 2-1 in Spain last time out and will now host Diego Alonso's side this evening.
Can Arsenal qualify for the Champions League knockout rounds tonight?
The simple answer is yes, they can.
However, they will need to take care of business themselves and hope for some help from Lens.
The first thing Arsenal have to do is beat Sevilla at the Emirates.
If they fail to do that, there is no possible way they can qualify for the last 16 this evening.
In fact, a defeat could leave them in a precarious position, while a draw would see Lens or PSV Eindhoven close the gap.
Pre-match press conference: Mikel Arteta (Champions League: Arsenal vs. Sevilla)
But even a win wouldn't be enough unless Lens beat PSV.
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If this were to happen, it would put the Gunners seven points clear of PSV and Sevilla with just two games left.
If Lens v PSV is a draw or the French side lose, the Gunners would be forced to wait for at least another gameweek.
But if they win, and the other result goes against them, Arsenal will still be in a strong position to qualify for the Champions League knockout stages in one of the next two matches.