The Seagulls are flying high this season and go into this weekend's game in fourth.
They have drawn their last three including a disappointing goalless draw at Norwich last weekend.
Graham Potter's men did beat City in a 3-2 thriller on the south coast last season as they came from two down to win late on.
City are a place above Brighton following their comfortable win over Burnley last Saturday.
Brighton v Man City: talkSPORT commentary
This Premier League clash will kick-off at 5:30pm on Saturday, October 30.
Hugh Woozencroft will be your host and commentary will come from Clive Tyldesley and former Southampton striker David Connolly.
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Brighton v Man City: Team news
Brighton will be without Danny Welbeck and Steven Alzate.
Adam Webster has been out with hamstring injury in recent weeks but could return this weekend.
Ferran Torres remains Man City's only major absentee after he fractured his right foot on international duty.
The Spain winger will be out until January.
Pep Guardiola has no other issues to deal with but will likely bring Kyle Walker, Ruben Dias and Jack Grealish back in after they were rested last weekend.
Brighton v Man City: Match facts
Having lost their first seven Premier League games against Man City by an aggregate score of 21-2, Brighton came from 0-2 down to win 3-2 in their last such meeting in May.
Manchester City have never lost back-to-back league meetings with Brighton, overall losing just four of their 22 previous such games against the Seagulls (W14 D4 L4).
Brighton scored more goals in their last match against Manchester City (3) than they had in their previous eight games against them in all competitions (2).
Each of Brighton's last three Premier League games have finished level, with their last two finishing 0-0. Since their promotion to the competition in 2017, the Seagulls have had more draws (53) and more goalless draws (19) than any other side in the competition.
Since their 3-2 defeat against Brighton in May, Manchester City have conceded just three further goals in their nine Premier League games (W6 D2 L1), keeping seven clean sheets in that run. Including that loss at Brighton, each of the Citizens' last seven goals conceded in the competition have come in the second half of games.
Between them, Manchester City (12) and Brighton (21) have faced the fewest shots on target in the Premier League this season, while they are also two of the three sides to have the lowest xG against totals in the competition this term (Man City 4.8, Brighton 8.1).
Brighton have been shown more yellow cards than any other side in the Premier League this season (22), with no player picking up more bookings than Seagulls defender Joël Veltman (4).
No player has created more chances from set plays this season than Brighton's Pascal Groß (11), while of all players with at least 10 chances created this term, the German has the highest share from set piece situations (69% - 11/16).
Man City's Raheem Sterling has scored four goals in four Premier League starts against Brighton, netting a hat-trick on his last visit to the Amex Stadium in July 2020. However, Sterling has scored just once from 13 attempts in the Premier League so far this season.
Man City's Kevin De Bruyne has scored in consecutive Premier League games for the first time since September 2020. Only once before has the Belgian scored in three consecutive appearances in the competition, doing so in September/October 2015.