Partey is the standout name in the Black Stars side, with Brighton defender Lamptey, Southampton midfielder Mohamed Salisu and Leicester's Daniel Amartey also forming part of the 26-man squad.
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Former Atletico Madrid midfielder Partey continues to star for Premier League table-toppers Arsenal and has proved pivotal for Mikel Arteta's side so far this season.
Lamptey, meanwhile, made his first appearance for Ghana back in September, after previously representing England at youth level.
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The 22-year-old, who was born in England to Ghanaian parents, has benefitted from swapping his international allegiance ahead of the World Cup in Qatar.
Salisu of Southampton also makes the cut, having only made his international debut in September as a half-time substitute against Brazil. Leicester City defender Amartey is another to get the nod.
Ghana face an uphill battle to qualify for the knockout round in Qatar after being draw in Group H alongside Portugal, Uruguay and South Korea.
Coach Otto Addo has recently faced calls to be axed after his side's poor run of form and underwhelming campaign at the Africa Cup of Nations in January.
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Ghana have managed just two victories in 12 games this year.
They drew 1-1 with Central African Republic, ranked 132 in the world by FIFA, in their first AFCON 2023 qualifier in June.
The Ghanaians also lost 4-1 to Japan, drew 0-0 with Chile, and lost 3-0 to Brazil. However, they did manage a 1-0 victory over Guatemala in a recent friendly.
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Ghana's best result at a World Cup came when they reached the quarter-finals in 2010, before losing out to Uruguay on penalties.