The 26-year-old registered a penalty in his side's 3-0 win over Everton in the league last weekend, but he missed out on Wednesday's 3-3 draw with Galatasaray due to a Champions League suspension.
Rashford is back in the squad for Man United's return to league action, and he is expected to feature in the starting side, as Erik ten Hag's side look to make it five wins from their last six league matches.
With that in mind, Sports Mole looks at how the forward has performed against Newcastle during his professional career.
Rashford has faced the Magpies on 12 occasions at first-team level, boasting a record of seven wins, two draws and three defeats against them, scoring four goals and registering five assists in the process.
As expected, the bulk of those matches (10) have taken place in the Premier League, with Rashford winning six, drawing two and losing two of his previous league encounters with Newcastle.
Rashford has also tackled the Magpies twice in the EFL Cup, scoring once, with his goal coming in the final earlier this year, but he was also a part of the side that suffered a 3-0 defeat to Eddie Howe's side in this season's tournament, coming off the bench in the second period.
The attacker has managed four goals and five assists against Newcastle in the Premier League, and he has previous when it comes to impressing at St James' Park.
Indeed, he scored and provided an assist in a 2-0 Man United victory at the famous stadium during the second half of the 2018-19 campaign.
Arguably Rashford's best performance against Newcastle also came at St James' Park, with the Englishman scoring once and providing two assists in a 4-1 success for the Red Devils in the early stages of the 2020-21 campaign.
The forward has not managed to score in his last three Premier League games with the Magpies, though, which includes a 2-0 loss at St James' Park last term.
Rashford's penalty against Everton last weekend could potentially have kickstarted his campaign from a goal point of view, and he will now be bidding to help Man United move closer to the top four in the Premier League table.